Fig. 5

Transplanted drNPCs respond to migratory cues in vivo. A At 2 weeks post-transplant STEM121⁺ drNPCs are seen in both the anterior SVZ, near the site of transplant (A_i), and in the OB (A_ii, A_iii). B At 1 month post-transplant HuNu⁺ drNPCs are found in both the anterior SVZ, near the site of transplant (B_ai–B_aiv), and in the OB (B_bi–B_biv). Arrowheads indicate HuNu⁺/NSE⁺ cells; white boxes outline higher magnification insets; CC corpus callosum, LV lateral ventricle, GCL granule cell layer, MCL mitral cell layer, ONL olfactory nerve layer, GL glomerular layer; scale bars = 50 μm. n = 3 transplanted hemispheres