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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue

Fig. 4

GMSCs did not cause reverse mutation of S. typhimurium and chromosome aberration of CHL strain. a, b Under conditions of metabolic activation (presence of S9), positive control (50 μg/dish Dexon was for TA97, TA98, and TA102 strains, 2.0 μg/dish NaN3 was for TA100 and TA1535 strains), c, d non-metabolic activation (absence of S9), positive control (50 μg/dish Dexon was for TA97, TA98, and TA102 stains: 2.0 μg/dish NaN3 was for TA100 and TA1535 stains). Meanwhile, 0.1 ml/dish 0.9% NaCl was as negative control. e Chromosome aberration rates under metabolic activation (with S9 mix) and f non-metabolic activation (without S9 mix) with 6-h GMSC treatment. CP and mitomycin C served as a positive control with and without S9 mix, and 0.9% NaCl solution was used as a negative control. The data represent the mean ± SD of three separated experiments. NS means no significance; *p < 0.05, **p ≤ 0.01). N ≥ 3/group

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