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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice

Fig. 2

hAEC treatment did not affect the general exploratory locomotion and anxiety-like behavior in BTBR mice. ad Behavioral performance in the open field. a, b BTBR mice with vehicle treatment moved more than C57 mice in total distance and in the first 5 min. c, d There was no significant difference in the three groups in the center time. e, f Behavioral performance in the elevated plus maze. Vehicle-treated BTBR mice exhibited more open arm entries than C57 mice, and hAEC treatment did not significantly affect the percentage of time spent in the open arm or the number of open arm entries. g Vehicle-treated BTBR mice spent more time in the dark box than C57 mice, and hAEC injection did not reduce the time BTBR mice spent in the dark box. h Observational analysis showed no difference in the transitions among the groups. The data are presented as the mean ± SEM (n = 7–8). *P < 0.05, **P < 0.01, ***P < 0.001

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