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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human amniotic epithelial cell transplantation promotes neurogenesis and ameliorates social deficits in BTBR mice

Fig. 4

hAEC treatment increased BrdU- and DCX-positive cells in the DG of BTBR mice. ac Representative images of BrdU-labeled sections of the DG for each group. df Representative images of DCX-labeled sections of the SGZ for each group. gi The images are the magnified views of the boxed areas in df. jl Representative images of Prox1-labeled sections of the SGZ for each group. m Quantitative analysis of the number of BrdU-labeled cells in the hippocampal DG. C57 mice exhibited more BrdU+ cells in the DG compared to BTBR mice with vehicle treatment. After hAEC treatment, the number of BrdU+ cells increased in the DG of the BTBR mice. n Quantitative analysis of the number of DCX-labeled cells in the hippocampal SGZ. C57 mice also exhibited more DCX+ cells in the SGZ compared to vehicle-treated BTBR mice, and the number of DCX+ cells was also increased after hAEC treatment in BTBR mice. o Quantitative analysis of the density of Prox1-labeled cells in the DG. BTBR mice exhibited a lower density of Prox1+ cells in the DG compared to C57 mice, and the number of Prox1+ cells was also increased after hAEC treatment in BTBR mice. The data are presented as the mean ± SEM (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001. The scale bar in c = 50 μm and applies to ac; in f = 50 μm and applies to df; and in i = 20 μm and applies to gi; and in l = 50 μm and applies to jl

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