Fig. 4
From: Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer
Free replication-defective adenoviral vector displays poor intratumoral dissemination. Mice models containing mouse TRAMPC2 prostate tumor spheroids, growing in dorsal skinfold chambers injected with replication-defective AdGFP. Four days later, intravital microscopy showed that free adenoviral vector chemo-sensitized prostate tumors but displayed poor intratumoral dissemination. AdGFP (administered via a tail vein or locally) remains mostly on the surface of the tumor