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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer

Fig. 5

Packaging strategy of MSCs-E1s (a). MSCs-E1s successfully packaged and propagated replication-defective adenoviral vectors. We modified primary mesenchymal stem cells with E1A/B adenoviral packaging functions, MSC-E1s infected with replication-defective AdGFP and Adbic. MSCs-E1s loaded with AdGFP and Adbic successfully expressed GFP and p53 protein, respectively, in target tumor cells. b MODEL. MSCs-E1s are infected in a culture dish (ex vivo) with the viral vectors. Transfected MSCs-E1s are then administered in vivo, during which time they amplified the vector. Following integration into the tumor, the amplified vector released, where it can infect tumor cells (T) and suppress tumor cell growth

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