Fig. 9
From: Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer
Apoptosis induction by replication-defective adenoviral vectors loaded MSCs-E1s in TRAMPC2 H2B/GFP prostate tumors models. MSCs-E1s (5 × 105) loaded with 3 × 107 pfu/cell of Adbic (left) or AdLuc (3 × 107 pfu/cell) control (right) administered by a tail vein to male nude mice bearing TrampC2 tumors growing in dorsal skinfold chambers. GFP fluorescence was observed by intravital microscopy after MSCs-E1s injection (day 1) and on day 4. On day four, microscopic image of tumor in mice model that received Adbic-loaded MSCs-E1s showed typical bright, condensed nuclei (apoptosis) as indicated by the arrows. No such changes were observed in the control group that received Adluc-loaded MSCs-E1s