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Table 2 Summary of relevant information of the cynomolgus primates before/after transplantation

From: Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models

Items B-1 B-2 B-3 N-1 N-2 N-3 E-1 E-2 E-3 E-4 E-5 Mediana
Age (year) 7 7 7 6 7 7 6 7 7 7 6 7
Sex Male Male Male Male Male Male Male Male Male Male Male NA
Weight (kg) 6.5 5.6 8.0 6.2 6.4 6.1 5.8 4.6 6.6 6.6 6.6 6.4
Before expansion Cell number 3.0× 106 2.6× 106 3.6× 106 2.7× 106 2.4× 106 2.7× 106
CD34+ cell purity (%) 76.0% 64.9% 61.5% 73.6% 72.1% 72.1%
After expansion Total cell number 2.0 × 107 1.7 × 107 2.3 × 107 2.3 × 107 2.2 × 107 2.2 × 107
CD34+ cell purity (%) 71.7% 55.9% 57.1% 68.3% 65.6% 65.6%
Expansion fold Total cell 8.0 7.4 6.8 10.0 10.8 8.0
CD34+ cell 7.5 6.4 6.3 9.3 9.8 7.5
Transduction efficiency (GFP %) 31.4% 37.1% 32.8% 31.2% 40.4% 32.5%
Transplant dose (per kg) CD34+ cell 2.4 × 106 2.0 × 106 2.0 × 106 2.4 × 106 2.2 × 106 2.2 × 106
CD34 cell 2.6 × 107 2.0 × 107 2.5 × 107 2.6 × 107 2.5 × 107 2.0 × 107 2.5 × 107 2.5 × 107 2.5 × 107
Outcome Alive Alive Died Alive Alive Died Alive Alive Alive Alive Alive NA
  1. B-1, B-2, and B-3 were three animals in blank control; N-1, N-2, and N-3 were three animals in negative control; E-1~E-5 were five animals in experiment group
  2. aThe median was calculated of the experiment group
  3. Abbreviations: NA not applicable, GFP green fluorescent protein