Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Therapeutic angiogenesis using stem cell-derived extracellular vesicles: an emerging approach for treatment of ischemic diseases

Fig. 2

The mechanisms of angiogenesis induced by MSC-derived EVs in ischemic diseases. EVs from BM-MSCs, ADSCs, UC-MSCs, and PMSCs play an important role in neovascularization of ischemic diseases. MSC-derived EVs are enriched with specific cargo molecules including proteins (pSTAT3, IL-6, Wnt 3a, Wnt 4, and CXCR4) and miRNAs (miRNA-31, miRNA-125a, miRNA-181b, miRNA-210, miRNA-126, and miRNA-21). These proteins and miRNAs activate their related signal pathway to regulate the expression of angiogenic factors in endothelial cells. Abbreviation: IL-6, interleukin-6; FIH1, hypoxia-inducible factor 1-alpha inhibitor; HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; PTEN, phosphatase and tensin homolog

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512