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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Adipose-derived stem cells prevent the onset of bisphosphonate-related osteonecrosis of the jaw through transforming growth factor β-1-mediated gingival wound healing

Fig. 1

The treatment schedule used to induce BRONJ-like animals and the ADSC transplantation procedure. a Animals were divided into two groups, the healthy group (non-medication treated) and the BP group. The BP group was treated with zoledronic acid (ZOL) and dexamethasone (DEX). After the sixth dose of ZOL+DEX treatment, the bilateral premolars were extracted in both the healthy and BP groups. At 2 weeks and 8 weeks post extraction, samples were collected. b The procedure for tooth extraction and an extracted tooth (bar = 2 mm). c Animals were divided into two groups: the hydroxyapatite (HA) group and the ADSC group. Both groups were treated with ZOL+DEX once per week and followed the same schedule used to induce BRONJ-like animals. d The two groups were subjected to extraction of the bilateral premolars. Simultaneously, after tooth extraction, the HA group was filled with hydroxyapatite, and the ADSC group was filled with ADSCs that were incubated on HA. Arrows indicate filled HA or ADSC-HA complex

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