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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs

Fig. 4

microRNA profiles of UN-Exo and OD-Exo via microRNA sequencing. a MicroRNA levels in OD-Exo significantly changed when compared with that in UN-Exo, 28 microRNAs significantly changed, of which 7 increased and 21 decreased. b Four bioinformatics tools (TargetScan, miRTarBase, miRDB, and miRWalk) were used to analyze genes targeted by differentially expressed microRNAs, for example, hsa-miR-27a-5p. c All genes targeted by differentially expressed microRNAs were shown in the mRNA-microRNA network. d mRNA-microRNA network showed 16 genes in TGFβ signaling were targeted by 15 differentially expressed microRNAs. e Consistent with the microRNA sequencing, hsa-miR-5100 and hsa-miR-1260a were increased; hsa-miR-210-3p and hsa-miR-10b-5p were decreased by qPCR analysis

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Stem Cell Research & Therapy

ISSN: 1757-6512