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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Predifferentiated amniotic fluid mesenchymal stem cells enhance lung alveolar epithelium regeneration and reverse elastase-induced pulmonary emphysema

Fig. 2

Transplantation of LEPLCs reduced emphysematous histopathologic changes and downregulated the expression of emphysema-related genes in the PPE-induced pulmonary emphysema mouse model. Effects of LEPLCs treatment on tissue regeneration and reversal of lung emphysema. Lung tissues were collected at week 6 post-PPE treatment. a H&E stained histological sections from each group. Scale bar = 100 μm. b H&E staining was calculated as histopathological scores, n ≥ 5. Quantitative real-time RT-PCR was performed to analyze the mRNA expression levels of emphysema-related genes, c elastin, d, Vegfa, e Icam-1, f Mmp-9, and g Spa. Values were normalized to the glyceraldehyde-3-phosphate dehydrogenase (Gapdh) gene and expressed in relation to the PBS group. Data are represented as the mean ± SD; n ≥ 5 per group. *, p < 0.05; **, p < 0.01; ***, p < 0.001

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