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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion

Fig. 3

PreDSCs inhibited the resorption rate in the abortion-prone CBA/J♀ × DBA/2♂ combination. preDSCs, HFFs, or PBS were injected on day 2 of gestation in CBA/J mice mated to DBA/2 mice or control BALB/c mice, and the rate of embryo resorption (percentage of reabsorbed embryos referred to the total number of embryo implantations) was determined on day 14 of gestation. a The resorption rate (mean ± SD) was significantly higher in the abortion-prone CBA/J♀ × DBA/2♂ combination than in the control CBA/J♀ × BALB/c♂ combination (*P < 0.01). The injection of preDSCs significantly decreased the abortion rate in CBA/J♀ × DBA/2♂ matings (**P < 0.001). The injection of HFFs increased the abortion rate, but not significantly. b PreDSCs were detected by human Cyt B PCR in the blood and spleen of BALB/c-mated pregnant CBA/J mice and in the spleen of DBA/2-mated pregnant CBA/J mice in which preDSCs were injected. None of the control mice, in which preDSCs were not injected (PBS), was positive. Murine Cyt B PCR was positive in all samples

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