Fig. 1

The schematic illustration of the general structure of Lgr5. a Lgr5 comprises of a signal peptide (blue) followed by 17 leucine-rich repeat (LRR) domains (gray). Also, it contains a linker region between the last LRR and the first transmembrane (TM) domain, followed by a seven helical TM domain homologs to rhodopsin-like G protein receptors (GPCRs). b The diagram showing the structure of human Lgr5 is produced by GPCRdb (http://docs.gpcrdb.org/index.html). ICL, intracellular loops; ECL, extracellular loops