Table 1 Lgr5-mediated stimulation of tumor growth in glioma
Authors | Tumor models | Conclusions | Mechanisms |
|---|---|---|---|
Vieira et al. [108] | Neuroblastoma cell lines (SK-N-BE(2)-C, IMR32, NGP, SH-SY5Y, GIMEN, and SK-N-NAS) | Lgr5 stimulated tumor growth and proliferation | Regulation of MEK/ERK and Akt pro-survival signaling pathways |
Zhang et al. [123] | Adult glioma patients; primary glioma cells | Lgr5 is a new functional glioma stem cell (GSC) marker involved in EMT and prognostic indicator of glioma | Stimulation of EMT by activating the Wnt/β-catenin pathway and maintenance of GSC stemness by modulating the expression of SOX2, Nanog, CD133, CD44, CD24, and EpCAM |
Xie et al. [60] | Glioblastoma patient-derived stem cell (GSC) cultures | Stimulation of tumorigenicity and invasion by Lgr5 | Regulation of the interactions between tumor cells and their microenvironment through extracellular matrix and collagen signaling pathways |