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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Harnessing the secretome of adipose-derived stem cells in the treatment of ischemic heart diseases

Fig. 2

Paracrine effects of the ASC secretome and involved pathways. ASCs secrete IGF-1, SOD-3, miRNA-301a, and exosomes for improving the effect of anti-apoptosis or pro-survival through regulating cell cycle, N-Cadherin/ERK/Nrf2, ASK-1 and NFγB/p38/JNK, Wnt/β-Catenin, cyclin D1, Bcl-2 and Bax, respectively. ASC-derived microvesicles perform the pro-angiogenesis effect via delivery of miRNA-126 and miRNA-31 through ERK1/2/MAPK and FIH-1 pathways, respectively. The conditioned medium of ASCs exerts the anti-inflammation effect through IFN-γ/IDO and PGE2/EP2/4 signaling pathways, which also can recruit circulating EPCs through CXCL12/SDF-1α pathway. The anti-cardiac remodeling effect is mediated by exosomes through MAPK/PI3K pathway and HGF released from ASCs

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