Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells

Fig. 1

DFX enhances BFU-E colony formation proficiency of CD34+ HS/PCs. Quantitative analysis of CFU-GEMM, CFU-GM and BFU-E derived by CD34+ cells isolated from human umbilical cord blood (hUCB; upper panel) or mobilized bone marrow-derived from adult healthy subjects (hmBM; lower panel) and cultured without DFX, with 20 μM DFX and with 20 μM DFX + NAC 10 mM. DFX and NAC were added to methylcellulose-based medium at time of plating, and colonies were detected and enumerated after 14 days of culture. Results shown represent the mean ± SD of three independent experiments. (*p < 0.05 vs CTRL). Representative images of CFU-GEMM, CFU-GM and BFU-E scored under an inverted microscope (magnification × 40) are shown

Back to article page