Fig. 7From: Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cellsProposed mechanism of action of DFX in healthy HS/PCs and leukemia cell lines. DFX is shown to induce enhanced mitochondrial ROS generation thereby activating redox signalling-mediated mitochondrial biogenesis and differentiation. In addition, ROS promote stabilization of the active phosphorylated state of STAT1, inducing the expression of IFN-related genes. NAC co-incubation (red line) counteracts DFX downstream effects while FLUDA treatment (blue line), although inhibiting STAT1 activation and IFN-related genes expression, is not able to affect DFX-induced differentiation. See “Discussion” for further detailsBack to article page