Fig. 3

CXCR4 high-expressing ERCs protect against DSS-induced severe colitis. SDF-1-pretreated ERCs (a) attenuated the body weight loss and (b) alleviated the Disease Activity Index (DAI) of DSS-induced colitis in mice. c, d Mice were sacrificed at day 10 after DSS induction. The photograph shows colonic specimens from each group of mice. e Colon specimens were sectioned and stained with H&E. ^#ERCs indicated ERCs pretreated with SDF-1. *ERCs indicated inhibition of the function of SDF-1 by AMD3100. The p value was determined by one-way ANOVA. ***p < 0.001, **p < 0.01, *p < 0.05