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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Hedgehog pathway inhibition causes primary follicle atresia and decreases female germline stem cell proliferation capacity or stemness

Fig. 3

Pathological ovaries exhibited a decline in Hh pathway activity. a HE staining of a normal ovary and POF ovary. Bar is 200 μm. b The ratio of atretic follicles of normal and POF ovaries. c IHC shows that the Mvh-positive follicles and FGSCs dramatically disappeared in the POF model; green arrows are FGSCs, and black arrow represents primordial follicles, the scale is 100 μm. df mRNA and protein expression levels of Mvh, Oct4, Gli1, Ptch1, and Cyclin D1. *p < 0.05 and **p < 0.01

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