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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

Fig. 4

Electrophysiological measurements from FXN-deficient hvCAS derived from hESCs and hiPSCs relative to their respective healthy controls. a Representative action potentials and isochronal maps from control hESC-hvCAS transduced with non-targeting lentivirus (Lv-shNT), hESC-hvCAS transduced with Lv-shFXN, control hiPSC-hvCAS, and FRDA-hiPSC-hvCAS. b Maximum capture frequency (MCF) for (i) Lv-shNT (n = 32) vs. Lv-shFXN (n = 33) hESC-hvCAS and (ii) healthy control hiPSC-hvCAS (n = 20) vs. FRDA-hiPSC-hvCAS (n = 30). c Action potential duration at 50% repolarization (APD50) and 90% repolarization (APD90) derived from optical mapping of (i and iii) Lv-shNT vs. Lv-shFXN-transduced hESC-hvCAS and (ii and iv) healthy control vs. FRDA-hiPSC-hvCAS. Data were generated from 3 to 9 independent batches of differentiation. All electrophysiology data are shown as median with interquartile range. Statistical significance indicated by *p < 0.05, **p < 0.01, and ***p < 0.001

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