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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stem cell repression of Th17 cells is triggered by mitochondrial transfer

Fig. 4

Effects of BM-MSC mitochondria on T cell OXPHOS. After co-culture (4 h) with BM-MSCs pre-activated (aMSC) or not with TNF-α/IFN-γ, T cells were cultured for 48 h and then their oxygen consumption rates (OCRs) were measured (Seahorse system). a Results of a representative experiment at 48 h after co-culture. The T cell OCR values were determined in basal conditions and after consecutive addition of oligomycin, FCCP, and rotenone/antimycin A. b OCR quantification (basal condition) in Th17 cells co-cultured or not with BM-MSCs pre-activated (aMSC) or not (MSC) with TNF-α and IFN-γ. c OCR quantification to evaluate the maximal respiration in Th17 cells co-cultured or not with BM-MSCs pre-activated (aMSC) or not (MSC) with TNF-α and IFN-γ. Data are the mean values ± SEM of 4 independent experiments using BM-MSCs from three healthy donors (MSC to T cell ratio = 1:25)

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