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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling

Fig. 3

IFN-γ impacts the differential progress of LT-HSC to ST-HSC and MPPs in the liver and BM. The proportion of Lin c-kit+ sca-1+ (LSK) cells and LT-HSC, ST-HSC, and MPP cells in the flow plot was gated from LSK cells from the adult C57BL/6j mice and GKO mouse liver or BM (n = 5–10) (a, c). Statistical analysis of the percentage of LT-HSC, ST-HSC, and MPP cells gated from the LSK cells in the adult mice liver and BM (b and d). *p < 0.05. e Flow cytometry plots showing the percentage of LSKs among the Lin cells and CD48 cells gated from LSK cells from the bone marrow or liver of adult mice after hydrodynamic injected with pLive or pLive-IFN-γ plasmid for 1–8 weeks. (n = 5–10). Bars represent the mean ± SEM of three independent experiments

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