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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling

Fig. 3

IFN-γ impacts the differential progress of LT-HSC to ST-HSC and MPPs in the liver and BM. The proportion of Lin− c-kit+ sca-1+ (LSK) cells and LT-HSC, ST-HSC, and MPP cells in the flow plot was gated from LSK cells from the adult C57BL/6j mice and GKO mouse liver or BM (n = 5–10) (a, c). Statistical analysis of the percentage of LT-HSC, ST-HSC, and MPP cells gated from the LSK cells in the adult mice liver and BM (b and d). *p < 0.05. e Flow cytometry plots showing the percentage of LSKs among the Lin− cells and CD48− cells gated from LSK cells from the bone marrow or liver of adult mice after hydrodynamic injected with pLive or pLive-IFN-γ plasmid for 1–8 weeks. (n = 5–10). Bars represent the mean ± SEM of three independent experiments

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