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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling

Fig. 4

IFN-γ inhibits the development of liver T progenitor cells in vivo. The proportion of T progenitor cells (the whole range of DN cells) and DN1, DN2, DN3, and DN4 cells in the flow plot was gated from DN cells from the adult C57BL/6j mice and GKO mouse liver (a); adult mice overexpressing IFN-γ and the control mice (c) (n = 5–10). b, d Statistical analysis for the percentage DN1, DN2, DN3, and DN4 cells gated from the whole DN cells in the adult C57BL/6j mice and GKO mouse liver (b) and the adult mice overexpressing IFN-γ and the control mice (d). Bars represent the mean ± SEM of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001. e Flow cytometry plots showing the expression of Ki67 on total DN cells and DN1 cells from the adult mouse liver after hydrodynamic injection with plasmid pLive or pLive-IFN-γ for 8 weeks

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Stem Cell Research & Therapy

ISSN: 1757-6512