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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling

Fig. 5

IFN-γ impacts the differentiation rate from LSK cells to T progenitor cells and γδT cells. a The proportion of LSK cells and T progenitor cells (DN1, DN2, DN3, and DN4 cells) in the flow plot was gated from Lineage cells and the expression of Ki67 on total LSK cells and DN cells after the adult mice liver or BM LSK cells were co-cultured with OP9-DL1 cells, with or without IFN-γ stimulating at days 7 (n = 5–10). b The expression of Ki67 on total LSK cells and DN cells after the adult mouse liver or BM LSK cells were co-cultured with OP9-DL1 cells, with or without IFN-γ stimulation at day 0 and day 7 (n = 5–10). c The proportion of γδT cells and αβT cells in the flow plot after the adult C57BL/6j mice liver or BM LSK cells were co-cultured with OP9-DL1 cells, with or without IFN-γ stimulating at day 21. d Apoptosis levels of liver LSK cells and BM LSK cells in the co-cultured system were detected using 7-AAD at day 21

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