Fig. 2
From: Epidermal stem cells in wound healing and their clinical applications
Schematic of the canonical Wnt signaling pathway. In the absence of Wnt signaling (left), β-catenin binds to axin, APC, and GSK3-β and becomes phosphorylated and targeted for degradation. β-Catenin also exists in a cadherin-bound form and regulates cell–cell adhesion. In the presence of Wnt signaling (right), β-catenin is uncoupled from the degradation complex and translocates to the nucleus, where it binds transcription factors, thereby activating target genes