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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo

Fig. 8

Safranin O and fast green staining of rabbit menisci after five different treatments for 3 months. ad The wounded meniscus treated with saline at day 90 post-surgery. eh The wounded meniscus treated with KGN at day 90 post-surgery. il The wounded meniscus treated with KGN-PRP gel at day 90 post-surgery. mp The wounded meniscus treated with BMSCs-containing PRP gel at day 90 post-surgery. qt The wounded meniscus treated with BMSC-containing KGN-PRP gel at day 90 post-surgery. The images of d, h, l, p, and t were enlarged box areas in the images of c, g, k, o, and s, respectively. Large unhealed wound areas were still found in the saline-treated meniscus (red arrows in ac) and KGN-treated meniscus (yellow arrows in eg). Although the wounds were healed with KGN-PRP gels, new formed tissues were thinner than around tissues (black arrows in ik) and less cells in new formed tissues were fibrocartilage-like cells (pink arrow in l) than the wounds treated either with BMSCs-containing PRP gel (mp) or with BMSCs-containing KGN-PRP gels (qt). There was no unhealed wound area found in the meniscus treated either with BMSCs-containing PRP gel or with BMSCs-containing KGN-PRP gel, but the new formed tissues in these two groups were different, more collagen fiber-like tissues were found in PRP-BMSC-treated meniscus (black dash arrows in mp), and more cartilage-like cells were found in the wound area treated with BMSCs-containing KGN-PRP gel (white arrows in qt)

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