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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: The growth inhibitory effect of human gingiva-derived mesenchymal stromal cells expressing interferon-β on tongue squamous cell carcinoma cells and xenograft model

Fig. 5

GMSCs/IFN-β attenuated tumor growth in vivo. a H&E staining for TSCC xenografted tumor nodules excised from experimental nude mice. b Representative graph of tumor growth and mean tumor volume at different time points during 4 weeks after inoculation are shown. GMSCs, GMSCs/vector, and GMSCs/IFN-β significantly decreased the tumor sizes compared with the PBS group, and especially, GMSCs/IFN-β treatment caused the most decreased tumor size in mice. c At the end point of treatment, mice were anesthetized and sacrificed. Then tumors were dissected and photographed. d Tumors of each group were collected and weighed. GMSCs/IFN-β treatment caused the most decreased tumor weight in mice compared with the PBS, GMSCs, or GMSCs/vector group. All data are shown as mean ± SD. *P < 0.05 versus the PBS group, #P < 0.05 versus the GMSCs/vector group

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Stem Cell Research & Therapy

ISSN: 1757-6512