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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells

Fig. 1

Screening of lncRNAs that are tightly correlated with human pluripotency. a Constituent numbers of RNA-seq data used in this study to screen candidate lncRNAs. b Unsupervised hierarchical clustering of 55 RNA-seq data from hiPSC (yellow), hESC (orange), and human somatic tissue (cyan) samples (FPKM ≥ 0.1). c Sample-specific modules identified by WGCNA. Two figures of each square respectively represent the correlation between a module and corresponding sample, and p value of the correlation value. Colors of squares correspond to different correlation types: positive correlation (red), negative correlation (blue), no correlation (white). d Top three human PSC-specific modules identified by WGCNA. e Twelve noncoding genes showing membership values above 0.8 with PGM module. f Expression of filtered 12 noncoding genes, which were identified by RNA-seq data of 55 samples. g Quantitative RT-PCR analyses of 11 lncRNAs’ expression levels in H9 and HEF cells. Error bars indicate SEM (n = 3). *p < .05; **p < .01; ***p < .001

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