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Table 1 Multiple linear regression for induced DNA DSB repair foci in MSCs indicates a strong multiplicative interaction (F = 4.8, p < 0.0001) between dose (positive effect with a coefficient of b = 2.26) and in vitro age (negative effect with a coefficient of b = − 0.24). In vitro age alone has no significant effect on the formation of DNA DSB foci

From: Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

 

Foci/cell

Foci/cell

Foci/cell

Foci/cell

− 95%

95%

Foci/cell

Foci/cell

− 95%

95%

Param.

St.Err.

T

p

Conf.Int.

Conf.Int.

Beta

St.Err. Beta

Conf.Int.

Conf.Int.

Const

2.299

0.524

4.388

0.0001

1.242

3.358

    

Dose

2.265

0.185

12.263

0.000

1.892

2.638

1.343

0.109

1.122

1.564

Age

− 0.112

0.101

− 1.107

0.2757

− 0.315

0.092

− 0.084

0.076

− 0.237

0.069

Dose × age

− 0.238

0.035

− 6.691

0.000

− 0.310

− 0.166

− 0.794

0.119

− 1.033

− 0.554

  1. Entries in italics indicate parameters that influence repair foci with statistical significance of p<0.05