Table 2 Multiple linear regression for radiation-induced micronuclei in aging MSCs. A dose-age interaction (p = 0.057) as suggested by ANOVA cannot be confirmed when in vitro age and radiation dose are evaluated by the strength of their individual effects and the compound effects. The majority of data in aged and irradiated MSCs suggest an additive interaction with age (constant shift to higher MN frequencies), rather than a sensitizing effect

From: Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability