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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis

Fig. 5

Heat shock treatment-induced SSC cell cycle inhibition. a The KEGG JAK-STAT signalling pathway responds to cell cycle progression and inhibition; the genes highlighted in red were enriched and upregulated. b Validation of the enriched and upregulated genes in the Jak-Stat signalling pathway by quantitative PCR. c Heat shock treatment-mediated S phase cell cycle arrest in in vitro-cultured SSCs 2 h after heat shock treatment. However, 18 h after heat shock treatment, S phase cycle arrest was eliminated, and the proportion of cells in S phase returned to a normal level

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