Table 3 Selected top 10 of KEGG pathway enrichment
From: High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis
Pathway ID | KEGG pathway | Up-genes | Down-genes | P value |
|---|---|---|---|---|
mmu04915 | Estrogen signaling pathway | Hsp90aa1, Hspa1l, Fos, Hspa1a, Creb5, Hspa1b | – | 1.29E−04 |
mmu04668 | TNF signaling pathway | Fos, Creb5, Socs3, Cxcl3, Il18r1, Csf1 | – | 2.74E−04 |
mmu04141 | Protein processing in endoplasmic reticulum | Hspa4l, Hsp90aa1, Hspa1l, Hsph1, Hspa1a, Dnaja1, Dnajb1, Hspa1b | – | 1.24E−04 |
mmu04060 | Cytokine-cytokine receptor interaction | Ccr9, Osm, Tnfrsf19, Inhbe, Ccr4, Il6ra, Il18r1, Il13, Csf1 | – | 7.87E−04 |
mmu04630 | Jak-STAT signaling pathway | Osm, Aox1, Socs3, Il6ra, Il13 | – | 1.07E−02 |
mmu04512 | ECM-receptor interaction | Itgb4, Sv2c | – | 9.24E−02 |
mmu03040 | Spliceosome | Hspa1l, Hspa1a, Hspa1b | – | 8.08E−02 |
mmu04210 | Apoptosis | Bcl2l11, Bbc3, Fos | – | 9.22E−02 |
mmu04151 | PI3K-Akt signaling pathway | Bcl2l11, Itgb4, Hsp90aa1, Osm, Creb5, Il6ra, Csf1 | – | 4.24E−02 |
mmu04010 | MAPK signaling pathway | Hspa1l, Fos, Hspa1a, Hspa1b | – | 1.96E−01 |