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Table 1 Characteristics of mouse experiments

From: Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies

First author Year Location Mice (sex, strain, weight) Number of each group Modeling method Modeling duration Type and source of MSCs Way of MSCs administrated Times of treatment Parameter
Guo-Chao Niu 2012 China Male, C57B L/6, 18~22 g DSS + Vechile (n = 10)
DSS + MSCs (n = 10)
DSS (5%) 30 Mouse UC-MSCs Tail vein injection 1 DAI, colon length, HS
Xiao-Wen He 2012 China Male, BALB/c mice, 19–21 g DSS + 4%PBS (n = 6)
DSS + MSCs (n = 6)
DSS (4%) 7 Mouse BM-MSCs Tail vein injection 3 DAI, colon length, HS
Xiao-Xi Xu 2018 China Male, BALB/c mice, 18–22 g DSS + 4%PBS (n = 8)
DSS + ERCs
(n = 8)
DSS (3%) 7 Mouse ERCs Tail vein injection 3 DAI, colon length
Jin Seok Park 2015 Korea Male, C57BL/6 mice, N/A DSS + PBS (n = 8)
DSS + mc-MSCs (n = 8)
DSS (2.5%) 6 MC-MSCs Tail vein injection 3 DAI, colon length, HS
Young-Sun Nam 2015 South Korea Female, C57BL/6, N/A DSS + PBS (n = 10)
DSS + MSCs (n = 10)
DSS (3.5%) 6 Mouse BM-MSCs Intraperitoneal injection 1 DAI, colon length
Wei-Xin Liu 2015 China Male, C57BL/6 mice, N/A DSS (n = 10)
DSS + MSCs (n = 10)
DSS (N/A) 7 Mouse BM-MSCs Tail vein injection 1 DAI
Forte 2015 Italy Male, C57BL/6 mice, N/A DSS (n = 4)
DSS + MSCs (n = 4)
DSS (1.5%) 9 Human AD-MSCs Irrigation 3 DAI, HS
Li Cao 2019 China Male, BALB/c mice, 21–23 g DSS + NS (n = 10)
DSS + EVs (n = 10)
DSS (3%) 7 EVs from Mouse BM-MSCs Intraperitoneal injection 7 DAI, colon length
  1. DSS dextran sodium sulfate, MSCs mesenchymal stem cells, PBS phosphate buffer saline, NS normal saline, EVs extracellular vesicles, ERCs endometrial regenerative cells, MC-MSCs mouse clonal MSCs, UC-MSCs umbilical cord MSCs, BM-MSCs bone marrow MSCs, AD-MSCs adipose-derived MSCs, DAI disease activity index, HS histopathological score