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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice

Fig. 1

Decitabine enhances and prolongs the anti-diabetic effects of UC-MSCs in T2D mice. T2D mice were randomly divided into the following groups: the T2D group (received PBS infusion), MSC group (received UC-MSC infusion), DAC group (received decitabine administration), and MSC + DAC group (received UC-MSC and decitabine infusion). Mice fed with a NCD served as the control (the normal group). a Blood glucose levels were detected consecutively after STZ injection. At 1 week, 2 weeks, and 4 weeks after treatment, the serum blood glucose (b) and serum insulin (c) concentrations of each group were measured. d Glucose tolerance was assessed by IPGTT. e Insulin tolerance was evaluated by IPITT. For IPITT, the results are presented relative to the initial blood glucose concentration. Values of a–e are the means ± SD; n = 6 mice per group; *P < 0.05, **P < 0.01. STZ, streptozotocin; T2D, type 2 diabetes; MSC, mesenchymal stem cells; DAC, decitabine; M+D, mesenchymal stem cells combined with decitabine; IPGTT, intraperitoneal glucose tolerance test; IPITT, intraperitoneal insulin tolerance test.

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Stem Cell Research & Therapy

ISSN: 1757-6512