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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR

Fig. 4

MiR-100 as a SHED-Exo-enriched miRNA that attenuates inflammation. a Top 20 differentially expressed miRNAs. Heatmap of exosomal miRNA expression profiles assessed by miRNA microarray analysis. Each row represents a miRNA and each column represents a sample. The color scale shown in the map indicates the expression levels of miRNAs across all samples: red shades represent high expression levels and blue shades represent lower expression levels. b Chondrocytes were transfected with the miR-100 mimic, miR-100 inhibitor, miR-100 mimic negative control, or miR-100 inhibitor negative control. Next, miR-100 levels were determined by RT-qPCR. Statistical analysis was performed using Student’s t test. c MiR-100 expression in SHED-Exo-treated chondrocytes was detected by RT-qPCR. Statistical analysis was performed using Student’s t test. d mRNA expression of MMP1, MMP9, MMP13, and ADAMTS5 was measured by RT-qPCR. Statistical analysis was performed using one-way ANOVA followed by Tukey’s test. Data with P values < 0.05 were considered significant; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.001, n = 3. All data are expressed as the mean ± SEM

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