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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Fig. 1

FH-iPSCs recapitulate FH phenotype in vitro. a DNA sequences depicting the mutated nucleotide g.10891C>T (c.97C->T, p.Q12X) in the LDLR exon 2 in FH-patient’s fibroblasts and iPSCs by contrast to normal human fibroblasts (Ctl). b Western blot analysis confirming the absence of LDLR protein in FH-iPSCs. c Representative confocal pictures of Dil-LDL internalization in ctl and FH-fibroblasts and in ctl and FH-iPSCs. Nuclei were counterstained with DAPI. Scale bar 50 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512