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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Fig. 4

Phenotypic rescue of corr-FH-iHeps. a Western blot analysis demonstrating the specificity of APOA2 promoter in corr-FH-iHeps. b Representative confocal images of Dil-LDL internalization in FH-iHeps, corr-FH-iHeps and Ctl iHeps. Nuclei were counterstained with DAPI. Scale bars: 100 μm. FACS analysis of internalized Dil-LDL levels: results are expressed as mean fluorescence intensity (MFI) relative to Ctl iHeps (n = 3). Statistical significance was determined by Student’s test, *P < 0.05, **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512