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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: miR-140-5p regulates the odontoblastic differentiation of dental pulp stem cells via the Wnt1/β-catenin signaling pathway

Fig. 5

Overexpression of Wnt1 reversed the inhibition of odontoblastic differentiation induced by miR-140-5p. a Alizarin red S staining showed the mineralized matrix deposition was the least in the mimic group and the most in the pcDNA3.1-Wnt1 group. The percent of positive cells in the pcDNA3.1-Wnt1+mimic group was similar to that of the control, mimic NC, and pcDNA3.1 NC groups; the differences among them were not statistically significant. b Western blot analysis showed the expressions of DSPP and DMP-1 proteins were the highest in the pcDNA3.1-Wnt1 group and the lowest in the mimic group. The expressions of DSPP and DMP-1 proteins in the pcDNA3.1-Wnt1+mimic group were similar to those of the control, mimic NC, and pcDNA3.1 NC groups; the differences among them were not statistically significant. *vs. the control group, P < 0.05; #vs. the mimic NC group, P < 0.05; @vs. the pcDNA3.1 NC group, P < 0.05; &vs. the mimic group, P < 0.05; $vs. the mimic+pcDNA3.1-Wnt1 group, P < 0.05. n = 6

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Stem Cell Research & Therapy

ISSN: 1757-6512