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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Human placenta-derived mesenchymal stem cells ameliorate orbital adipogenesis in female mice models of Graves’ ophthalmopathy

Fig. 1

Characterization studies on hTSHR A-subunit plasmid immunized mice. a Scheme of GO disease model construction. b Anti-TSHR Ab inhibition in the serum of disease mice at 12 weeks after last immunization with pTriEx-1.1 TSH receptor (TSHR) A-subunit plasmid in the muscle combined with electroporation. The serums from 5 normal animals and 55 GO disease animals were used in the analysis. Frontal MRI analysis shows protrusion of the eye and hypertrophy of the orbital volume shown as EOM area from c an age-matched normal and GO disease mice. In GO disease model, d the typical MRI analysis from BSS- (sham), hPMSC-, or steroid-injected groups after 4 weeks was presented. Significantly different values between the groups are indicated with asterisks (***p < 0.0005)

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Stem Cell Research & Therapy

ISSN: 1757-6512