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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: NLGP counterbalances the immunosuppressive effect of tumor-associated mesenchymal stem cells to restore effector T cell functions

Fig. 2

NLGP corrects TC-MSC and suppresses their inhibitory effects on T cell proliferation. a Diagrammatic representation of cross-talk between MSCs or TC-MSCs (NLGP treated/non-treated) and DC-T cells in co-culture. b Ki67 expression on CD8+ and CD4+ T cells in the presence of NLGP-treated MSC or TC-MSC culture supernatant as assessed by flow cytometry. Aggregate data obtained from six independent experiments performed. Bar diagrammatic representation of Ki67+CD8+and Ki67+CD4+T cells from MSC or TC-MSC co-culture with T cells in the presence and absence of NLGP (n = 6); *p < 0.05. c CD8+ T cells were cultured in the presence of TC-MSC supernatant and NLGP-treated TC-MSC supernatant for 48 h and were adoptively transferred (1 × 106) through tail vein into two groups of B16 melanoma tumor bearing mice (n = 9, in each group) and another group of tumor-bearing mice was kept untreated as control. Mean tumor area ± SD and survivability are presented, *p < 0.05

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