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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold

Fig. 6

BMP-2-transduced hBMSCs promote bone formation in vivo after 56 days of implantation in vivo. a H&E staining. No bone tissue was observed in the Protein group; in contrast, in the Gene group, bone tissues were observed at the margin and in the center area, suggesting uniform bone formation throughout the scaffolds. b OCN IHC. Bone formation in the Gene group was further confirmed by strong OCN deposition (brown), indicated by arrows. Bar = 200 μm. I, implanted scaffolds; M, muscle tissue

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