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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Mesenchymal stem cells restore the sperm motility from testicular torsion-detorsion injury by regulation of glucose metabolism in sperm

Fig. 5

Activation of Akt/GSK3 axis by MSCs modulates the expression of Akt and GSK3 expression of testicular torsion-detorsion-treated rats by secretion of stem cell factor. Amount of Akt, GSK3, and their phosphorylated forms in a sperm, b epididymis, and c testis revealed that MSCs reversed the inactivation of Akt/GSK3 caused by testicular torsion-detorsion, particularly in sperm and in testis. d Human stem cell factor (SCF) but not human insulin growth factor-1 (IGF-1) was detectable in testis of testicular torsion-detorsion (T)-treated rats treated with MSCs. Analysis of variance with the Tukey t test. *p < 0.05, n = 3 in each group

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