Groups | Mononuclear cells (%) | Neutrophils (%) | Collagen fibers (%) |
|---|
C | 33.6 ± 0.7 | 2.5 ± 0.3 | 0.20 ± 0.02 |
CLP |
SAL | 48.9 ± 1.4* | 19.2 ± 1.9* | 0.45 ± 0.06* |
AD-MSC | 39.2 ± 1.5*,# | 7.3 ± 0.8*,# | 0.35 ± 0.05*,# |
AD-MSC-EPA | 37.3 ± 1.3*,# | 3.5 ± 0.9*,#,‡ | 0.26 ± 0.03*,#,‡ |
- Fraction area of mononuclear cells, neutrophils, and collagen fibers in alveolar septa. Control (C) mice were subjected to an abdominal incision alone, while animals were subjected to cecal ligation and puncture (CLP) for induction of polymicrobial sepsis. After 24 h, the CLP group was further randomized to receive saline (0.05 mL, SAL) or adipose tissue-derived mesenchymal stromal cells (MSC) maintained under regular conditions (AD-MSC; 105 cells) or preconditioned with eicosapentaenoic acid (AD-MSC-EPA; 105 cells). n = 8/group. *Significantly different from the C group (P < 0.05). #Significantly different from the CLP-SAL group (P < 0.05). ‡Significantly different from the CLP-AD-MSC group (P < 0.05)
