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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K/AKT signaling pathway

Fig. 6

hAMSCs and hAMSC-CM promoted the migration and wound closure of heat stress-injured HaCAT and DFL cells in a wound scratch assay. Representative images of HaCAT (a) and DFL (c) scratch assays. The images were taken immediately after the scratches had been made and then after 48 h in the presence of hAMSCs and hAMSC-CM versus normal medium (NM). The red line indicates the initiatory areas without migrating cells. Quantitative analysis of the migration area was performed for HaCAT (b) and DFL (d), respectively. The in vitro wound-healing assay showed that hAMSCs and hAMSC-CM strongly improved the HaCAT and DFL wound closure compared with the NM group. Significance was measured using a two-way ANOVA. *P < 0.05, *P < 0.01, ***P < 0.001

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