Gene expression | Domain | P0 | P1 | P2 | P3 | P4 | P5 |
---|---|---|---|---|---|---|---|
Upregulated | BP | Regulation of cell proliferation | Extracellular matrix organization | Cell cycle process | Anatomical structure development | Animal organ development | Multicellular organism development |
Cellular developmental process | Extracellular structure organization | Cell cycle | Multicellular organism development | Multicellular organism development | Extracellular structure organization | ||
System development | Multicellular organism development | Chromosome organization | System development | System development | Extracellular matrix organization | ||
Regulation of developmental process | Anatomical structure development | Mitotic cell cycle process | Developmental process | Tissue development | Anatomical structure development | ||
Multicellular organism development | System development | Mitotic cell cycle | Animal organ development | Anatomical structure development | System development | ||
CC | Proteinaceous extracellular matrix | Proteinaceous extracellular matrix | Chromosome | Proteinaceous extracellular matrix | Proteinaceous extracellular matrix | Proteinaceous extracellular matrix | |
Extracellular matrix | Extracellular matrix | Chromosomal part | Extracellular matrix | Extracellular matrix | Extracellular matrix | ||
Extracellular region | Extracellular region | Chromosomal region | Extracellular region part | Focal adhesion | Extracellular region part | ||
Extracellular region part | Extracellular region part | Nuclear lumen | Striated muscle thin filament | Cell-substrate adherens junction | Collagen trimer | ||
Extracellular space | Extracellular space | Non-membrane-bounded organelle | Muscle thin filament tropomyosin | Cell-substrate junction | Extracellular region | ||
MF | Glycosaminoglycan binding | mRNA binding involved in posttranscriptional gene silencing | Protein binding | mRNA binding involved in posttranscriptional gene silencing | Oxidoreductase activity, oxidizing metal ions | Transcription factor activity, RNA polymerase ii core promoter proximal region sequence-specific binding | |
Ion binding | Collagen binding | Catalytic activity, acting on DNA | mRNA binding | Metalloendopeptidase activity | Metalloendopeptidase activity | ||
Platelet-derived growth factor-activated receptor activity | Extracellular matrix structural constituent | Carbohydrate derivative binding | Growth factor binding | [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity | Metal ion binding | ||
Heparin binding | Platelet-derived growth factor receptor binding | Adenyl ribonucleotide binding | Transforming growth factor beta-activated receptor activity | Ionotropic glutamate receptor binding | Cation binding | ||
Sulfur compound binding | Ion binding | Adenyl nucleotide binding | Oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor | Metallopeptidase activity | Xylosyltransferase activity | ||
Downregulated | BP | Cell proliferation | Biological adhesion | Anatomical structure morphogenesis | Anatomical structure morphogenesis | Cell adhesion | Regulation of multicellular organismal process |
Anatomical structure morphogenesis | Cell adhesion | Multicellular organismal process | Developmental process | Biological adhesion | Developmental process | ||
Circulatory system development | Multicellular organism development | System development | Vasculature development | Anatomical structure morphogenesis | Anatomical structure development | ||
Extracellular structure organization | Anatomical structure development | Cell adhesion | Cardiovascular system development | Signaling | Multicellular organism development | ||
Extracellular matrix organization | Anatomical structure morphogenesis | Developmental process | Anatomical structure development | Regulation of multicellular organismal process | Anatomical structure morphogenesis | ||
CC | Extracellular region part | Extracellular region | Extracellular region part | Extracellular region part | Extracellular region part | Extracellular region part | |
Extracellular space | Extracellular region part | Extracellular region | Extracellular region | Extracellular region | Extracellular region | ||
Extracellular matrix | Cell periphery | Extracellular space | Extracellular space | Extracellular space | Extracellular space | ||
Extracellular matrix component | Plasma membrane part | Extracellular matrix | Proteinaceous extracellular matrix | Extracellular matrix | Proteinaceous extracellular matrix | ||
Integral component of plasma membrane | Cell surface | Proteinaceous extracellular matrix | Extracellular matrix | Proteinaceous extracellular matrix | Extracellular matrix | ||
MF | Insulin-like growth factor binding | Cell adhesion molecule binding | Growth factor binding | Glycosaminoglycan binding | Glycosaminoglycan binding | Glycosaminoglycan binding | |
Collagen binding | Glycosaminoglycan binding | Receptor binding | Sulfur compound binding | Heparin binding | Sulfur compound binding | ||
Protein-lysine 6-oxidase activity | Growth factor binding | Extracellular matrix structural constituent | Heparin binding | Sulfur compound binding | Receptor binding | ||
Transition metal ion binding | Receptor binding | Glycosaminoglycan binding | Extracellular matrix structural constituent | Extracellular matrix structural constituent | Extracellular matrix structural constituent | ||
Protein binding | Integrin binding | Insulin-like growth factor binding | Growth factor binding | Growth factor binding | Heparin binding |