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Table 1 Top 5 enriched GO terms for pHPL-ASCs (upregulated) and FBS-ASCs (downregulated) at each passage (P0–P5). Related to Fig. 1

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression

Domain

P0

P1

P2

P3

P4

P5

Upregulated

BP

Regulation of cell proliferation

Extracellular matrix organization

Cell cycle process

Anatomical structure development

Animal organ development

Multicellular organism development

Cellular developmental process

Extracellular structure organization

Cell cycle

Multicellular organism development

Multicellular organism development

Extracellular structure organization

System development

Multicellular organism development

Chromosome organization

System development

System development

Extracellular matrix organization

Regulation of developmental process

Anatomical structure development

Mitotic cell cycle process

Developmental process

Tissue development

Anatomical structure development

Multicellular organism development

System development

Mitotic cell cycle

Animal organ development

Anatomical structure development

System development

CC

Proteinaceous extracellular matrix

Proteinaceous extracellular matrix

Chromosome

Proteinaceous extracellular matrix

Proteinaceous extracellular matrix

Proteinaceous extracellular matrix

Extracellular matrix

Extracellular matrix

Chromosomal part

Extracellular matrix

Extracellular matrix

Extracellular matrix

Extracellular region

Extracellular region

Chromosomal region

Extracellular region part

Focal adhesion

Extracellular region part

Extracellular region part

Extracellular region part

Nuclear lumen

Striated muscle thin filament

Cell-substrate adherens junction

Collagen trimer

Extracellular space

Extracellular space

Non-membrane-bounded organelle

Muscle thin filament tropomyosin

Cell-substrate junction

Extracellular region

MF

Glycosaminoglycan binding

mRNA binding involved in posttranscriptional gene silencing

Protein binding

mRNA binding involved in posttranscriptional gene silencing

Oxidoreductase activity, oxidizing metal ions

Transcription factor activity, RNA polymerase ii core promoter proximal region sequence-specific binding

Ion binding

Collagen binding

Catalytic activity, acting on DNA

mRNA binding

Metalloendopeptidase activity

Metalloendopeptidase activity

Platelet-derived growth factor-activated receptor activity

Extracellular matrix structural constituent

Carbohydrate derivative binding

Growth factor binding

[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Metal ion binding

Heparin binding

Platelet-derived growth factor receptor binding

Adenyl ribonucleotide binding

Transforming growth factor beta-activated receptor activity

Ionotropic glutamate receptor binding

Cation binding

Sulfur compound binding

Ion binding

Adenyl nucleotide binding

Oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

Metallopeptidase activity

Xylosyltransferase activity

Downregulated

BP

Cell proliferation

Biological adhesion

Anatomical structure morphogenesis

Anatomical structure morphogenesis

Cell adhesion

Regulation of multicellular organismal process

Anatomical structure morphogenesis

Cell adhesion

Multicellular organismal process

Developmental process

Biological adhesion

Developmental process

Circulatory system development

Multicellular organism development

System development

Vasculature development

Anatomical structure morphogenesis

Anatomical structure development

Extracellular structure organization

Anatomical structure development

Cell adhesion

Cardiovascular system development

Signaling

Multicellular organism development

Extracellular matrix organization

Anatomical structure morphogenesis

Developmental process

Anatomical structure development

Regulation of multicellular organismal process

Anatomical structure morphogenesis

CC

Extracellular region part

Extracellular region

Extracellular region part

Extracellular region part

Extracellular region part

Extracellular region part

Extracellular space

Extracellular region part

Extracellular region

Extracellular region

Extracellular region

Extracellular region

Extracellular matrix

Cell periphery

Extracellular space

Extracellular space

Extracellular space

Extracellular space

Extracellular matrix component

Plasma membrane part

Extracellular matrix

Proteinaceous extracellular matrix

Extracellular matrix

Proteinaceous extracellular matrix

Integral component of plasma membrane

Cell surface

Proteinaceous extracellular matrix

Extracellular matrix

Proteinaceous extracellular matrix

Extracellular matrix

MF

Insulin-like growth factor binding

Cell adhesion molecule binding

Growth factor binding

Glycosaminoglycan binding

Glycosaminoglycan binding

Glycosaminoglycan binding

Collagen binding

Glycosaminoglycan binding

Receptor binding

Sulfur compound binding

Heparin binding

Sulfur compound binding

Protein-lysine 6-oxidase activity

Growth factor binding

Extracellular matrix structural constituent

Heparin binding

Sulfur compound binding

Receptor binding

Transition metal ion binding

Receptor binding

Glycosaminoglycan binding

Extracellular matrix structural constituent

Extracellular matrix structural constituent

Extracellular matrix structural constituent

Protein binding

Integrin binding

Insulin-like growth factor binding

Growth factor binding

Growth factor binding

Heparin binding