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Table 2 Top 5 enriched GO terms for significantly up- and downregulated DEGs for FBS-ASCs between subsequent passages. Related to Fig. 2a

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression Domain P0–P1 P1–P2 P2–P3 P3–P4 P4–P5
Upregulated BP Cell migration Immune system process Protein-carbohydrate complex subunit organization
Immune system process Immune response Polysaccharide assembly with MHC class II protein complex
Leukocyte migration Defense response Protein-carbohydrate complex assembly
Localization of cell Response to stimulus Antigen processing and presentation of polysaccharide antigen via MHC class II
Cell motility Inflammatory response MHC class II protein complex assembly
CC Cell surface Plasma membrane MHC class II protein complex
Plasma membrane Cell periphery Lumenal side of endoplasmic reticulum membrane
Cell periphery Plasma membrane part Integral component of lumenal side of endoplasmic reticulum membrane
Integral component of membrane Intrinsic component of plasma membrane MHC protein complex
Extracellular region Integral component of plasma membrane Crlf-clcf1 complex
MF Receptor binding Receptor binding MHC class II receptor activity
Chemokine activity Receptor activity MHC class II protein complex binding
Receptor activity Molecular transducer activity MHC protein complex binding
Cytokine activity Peptide antigen binding Peptide antigen binding
Molecular transducer activity Chemokine activity Leptomycin b binding
Downregulated BP System development Multicellular organism development Protein-carbohydrate complex subunit organization Spliceosomal complex disassembly
Multicellular organism development System development Polysaccharide assembly with MHC class II protein complex Ribonucleoprotein complex disassembly
Developmental process Anatomical structure development Protein-carbohydrate complex assembly
Anatomical structure development Developmental process Antigen processing and presentation of polysaccharide antigen via MHC class II
Tissue development Anatomical structure morphogenesis MHC class II protein complex assembly
CC Vesicle Extracellular region part MHC class II protein complex U2-type post-mRNA release spliceosomal complex
Extracellular region Extracellular region Lumenal side of endoplasmic reticulum membrane Post-mRNA release spliceosomal complex
Extracellular region part Extracellular space Integral component of lumenal side of endoplasmic reticulum membrane U2-type spliceosomal complex
Extracellular space Cell periphery MHC protein complex
Cell periphery Plasma membrane Crlf-clcf1 complex
MF Glycosaminoglycan binding Cell adhesion molecule binding MHC class II receptor activity
Cell adhesion molecule binding Receptor binding MHC class II protein complex binding
Heparin binding Cadherin binding MHC protein complex binding
Sulfur compound binding Heparin binding Peptide antigen binding
Fibronectin binding Growth factor binding Leptomycin b binding