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Table 3 Top 5 enriched GO terms for significantly up- and downregulated DEGs for pHPL-ASCs between subsequent passages. Related to Fig. 2b

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression Domain P0–P1 P1–P2 P2–P3 P3–P4 P4–P5
Upregulated BP Immune system process Regulation of multicellular organismal process Latent virus replication Positive regulation of heart rate by epinephrine-norepinephrine
Immune response Regulation of multicellular organismal development Regulation of RNA binding transcription factor activity Positive regulation of heart rate by epinephrine
Inflammatory response Animal organ morphogenesis Modulation by host of viral RNA-binding transcription factor activity Regulation of blood pressure
Defense response Response to external stimulus Modulation by host of RNA binding by virus Positive regulation of stress fiber assembly
Cell surface receptor signaling pathway Inflammatory response Regulation of DNA strand elongation Negative regulation of smooth muscle cell migration
CC Plasma membrane part Proteinaceous extracellular matrix Chloride channel complex Muscle thin filament tropomyosin
Intrinsic component of plasma membrane Extracellular matrix Alpha DNA polymerase:primase complex Striated muscle thin filament
Integral component of plasma membrane Extracellular region Ion channel complex Sarcoglycan complex
Plasma membrane Extracellular region part Transmembrane transporter complex Bleb
Cell surface Extracellular space DNA replication factor a complex Filamentous actin
MF Receptor activity Receptor binding Chloride channel activity Prostaglandin-endoperoxide synthase activity
Molecular transducer activity Integrin binding Anion channel activity Actin binding
Signal transducer activity Calcium ion binding Chloride transmembrane transporter activity N-Acetylglucosamine-6-sulfatase activity
Signaling receptor activity Sulfur compound binding Alkylglycerophosphoethanolamine phosphodiesterase activity Structural constituent of muscle
Chemokine activity Scavenger receptor activity Inorganic anion transmembrane transporter activity Arylsulfatase activity
Downregulated BP Cell cycle Positive regulation of heart rate by epinephrine-norepinephrine
Cell cycle process Positive regulation of heart rate by epinephrine
Chromosome organization Regulation of blood pressure
Mitotic cell cycle Positive regulation of stress fiber assembly
Mitotic cell cycle process Negative regulation of smooth muscle cell migration
CC Chromosome Muscle thin filament tropomyosin
Chromosomal part Striated muscle thin filament
Chromosomal region Sarcoglycan complex
Intracellular non-membrane-bounded organelle Bleb
Non-membrane-bounded organelle Filamentous actin
MF Protein binding Prostaglandin-endoperoxide synthase activity
Catalytic activity, acting on DNA Actin binding
Adenyl ribonucleotide binding N-Acetylglucosamine-6-sulfatase activity
ATP binding Structural constituent of muscle
Adenyl nucleotide binding Arylsulfatase activity