Table 3 Top 5 enriched GO terms for significantly up- and downregulated DEGs for pHPL-ASCs between subsequent passages. Related to Fig. 2b

Upregulated

BP

Immune system process

Regulation of multicellular organismal process

Latent virus replication

Positive regulation of heart rate by epinephrine-norepinephrine

–

Immune response

Regulation of multicellular organismal development

Regulation of RNA binding transcription factor activity

Positive regulation of heart rate by epinephrine

–

Inflammatory response

Animal organ morphogenesis

Modulation by host of viral RNA-binding transcription factor activity

Regulation of blood pressure

–

Defense response

Response to external stimulus

Modulation by host of RNA binding by virus

Positive regulation of stress fiber assembly

–

Cell surface receptor signaling pathway

Inflammatory response

Regulation of DNA strand elongation

Negative regulation of smooth muscle cell migration

–

CC

Plasma membrane part

Proteinaceous extracellular matrix

Chloride channel complex

Muscle thin filament tropomyosin

–

Intrinsic component of plasma membrane

Extracellular matrix

Alpha DNA polymerase:primase complex

Striated muscle thin filament

–

Integral component of plasma membrane

Extracellular region

Ion channel complex

Sarcoglycan complex

–

Plasma membrane

Extracellular region part

Transmembrane transporter complex

Bleb

–

Cell surface

Extracellular space

DNA replication factor a complex

Filamentous actin

–

MF

Receptor activity

Receptor binding

Chloride channel activity

Prostaglandin-endoperoxide synthase activity

–

Molecular transducer activity

Integrin binding

Anion channel activity

Actin binding

–

Signal transducer activity

Calcium ion binding

Chloride transmembrane transporter activity

N-Acetylglucosamine-6-sulfatase activity

–

Signaling receptor activity

Sulfur compound binding

Alkylglycerophosphoethanolamine phosphodiesterase activity

Structural constituent of muscle

–

Chemokine activity

Scavenger receptor activity

Inorganic anion transmembrane transporter activity

Arylsulfatase activity

–

Downregulated

BP

–

Cell cycle

Positive regulation of heart rate by epinephrine-norepinephrine

–

–

–

Cell cycle process

Positive regulation of heart rate by epinephrine

–

–

–

Chromosome organization

Regulation of blood pressure

–

–

–

Mitotic cell cycle

Positive regulation of stress fiber assembly

–

–

–

Mitotic cell cycle process

Negative regulation of smooth muscle cell migration

–

–

CC

–

Chromosome

Muscle thin filament tropomyosin

–

–

–

Chromosomal part

Striated muscle thin filament

–

–

–

Chromosomal region

Sarcoglycan complex

–

–

–

Intracellular non-membrane-bounded organelle

Bleb

–

–

–

Non-membrane-bounded organelle

Filamentous actin

–

–

MF

–

Protein binding

Prostaglandin-endoperoxide synthase activity

–

–

–

Catalytic activity, acting on DNA

Actin binding

–

–

–

Adenyl ribonucleotide binding

N-Acetylglucosamine-6-sulfatase activity

–

–

–

ATP binding

Structural constituent of muscle

–

–

–

Adenyl nucleotide binding

Arylsulfatase activity

–

–