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Table 4 Top 5 enriched GO terms for significantly up- and downregulated DEGs for FBS-ASCs between P0 and subsequent passages. Related to Fig. 3a

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression Domain P0–P1 P0–P2 P0–P3 P0–P4 P0–P5
Upregulated BP Cell migration Immune system process Immune system process Immune system process Immune system process
Immune system process Immune response Defense response Immune response Immune response
Leukocyte migration Defense response Immune response Cell surface receptor signaling pathway Defense response
Localization of cell Regulation of immune system process Inflammatory response Response to stimulus Response to stimulus
Cell motility Cell surface receptor signaling pathway Response to stimulus Defense response Cell surface receptor signaling pathway
CC Cell surface Plasma membrane Plasma membrane Plasma membrane part Intrinsic component of plasma membrane
Plasma membrane Cell periphery Cell periphery Intrinsic component of plasma membrane Plasma membrane
Cell periphery Plasma membrane part Plasma membrane part Integral component of plasma membrane Plasma membrane part
Integral component of membrane Intrinsic component of plasma membrane Intrinsic component of plasma membrane Plasma membrane Integral component of plasma membrane
Extracellular region Integral component of plasma membrane Integral component of plasma membrane Cell periphery Cell periphery
MF Receptor binding Receptor activity Receptor activity Receptor activity Receptor binding
Chemokine activity Molecular transducer activity Molecular transducer activity Molecular transducer activity Receptor activity
Receptor activity Receptor binding Chemokine activity Receptor binding Molecular transducer activity
Cytokine activity Chemokine activity Receptor binding Peptide antigen binding Peptide antigen binding
Molecular transducer activity Chemokine receptor binding Signaling receptor activity Chemokine activity Chemokine activity
Downregulated BP System development Anatomical structure development System development Anatomical structure development System development
Multicellular organism development Multicellular organism development Multicellular organism development Developmental process Developmental process
Developmental process Anatomical structure morphogenesis Cell adhesion Multicellular organism development Multicellular organism development
Anatomical structure development Nervous system development Biological adhesion System development Anatomical structure development
Tissue development System development Developmental process Anatomical structure morphogenesis Anatomical structure morphogenesis
CC Vesicle Extracellular region Extracellular region part Extracellular region part Extracellular region part
Extracellular region Extracellular region part Proteinaceous extracellular matrix Extracellular region Cell periphery
Extracellular region part Cell periphery Extracellular region Proteinaceous extracellular matrix Proteinaceous extracellular matrix
Extracellular space Extracellular space Extracellular matrix Extracellular matrix Extracellular region
Cell periphery Extracellular matrix Extracellular space Extracellular space Plasma membrane
MF Glycosaminoglycan binding Cell adhesion molecule binding Glycosaminoglycan binding Sulfur dioxygenase activity Cell adhesion molecule binding
Cell adhesion molecule binding Neuropilin binding Heparin binding Glycosaminoglycan binding Cadherin binding
Heparin binding Transporter activity Receptor binding Heparin binding Receptor binding
Sulfur compound binding Cadherin binding Sulfur compound binding Cell adhesion molecule binding Neuropilin binding
Fibronectin binding Protein tyrosine kinase activator activity Ion binding Cadherin binding Actin binding