Gene expression | Domain | P0–P1 | P0–P2 | P0–P3 | P0–P4 | P0–P5 |
---|---|---|---|---|---|---|
Upregulated | BP | Immune system process | Immune system process | Immune system process | Immune system process | Immune system process |
Immune response | Immune response | Immune response | Immune response | Immune response | ||
Inflammatory response | Inflammatory response | Response to external stimulus | Response to external stimulus | Response to external stimulus | ||
Defense response | Defense response | Defense response | Defense response | Defense response | ||
Cell surface receptor signaling pathway | Cellular response to chemical stimulus | Cellular response to chemical stimulus | Inflammatory response | Cellular response to chemical stimulus | ||
CC | Plasma membrane part | Extracellular region | Extracellular region | Extracellular region | Extracellular region | |
Intrinsic component of plasma membrane | Extracellular region part | Plasma membrane | Intrinsic component of plasma membrane | Extracellular region part | ||
Integral component of plasma membrane | Plasma membrane part | Cell periphery | Integral component of plasma membrane | Plasma membrane part | ||
Plasma membrane | Intrinsic component of plasma membrane | Intrinsic component of plasma membrane | Plasma membrane part | Extracellular space | ||
Cell surface | Extracellular space | Plasma membrane part | Extracellular region part | Plasma membrane | ||
MF | Receptor activity | Receptor activity | Receptor activity | Receptor activity | Receptor binding | |
Molecular transducer activity | Receptor binding | Glycosaminoglycan binding | Molecular transducer activity | Receptor activity | ||
Signal transducer activity | Molecular transducer activity | Molecular transducer activity | Receptor binding | Molecular transducer activity | ||
Signaling receptor activity | Glycosaminoglycan binding | Receptor binding | Glycosaminoglycan binding | Glycosaminoglycan binding | ||
Chemokine activity | Cytokine binding | Sulfur compound binding | Peptide binding | Signal transducer activity | ||
Downregulated | BP | – | Cell cycle process | Anatomical structure morphogenesis | Cell cycle process | Cell cycle process |
– | Cell cycle | Developmental process | Cell division | Cell division | ||
– | Mitotic cell cycle | Anatomical structure development | Anatomical structure morphogenesis | Chromosome segregation | ||
– | Mitotic cell cycle process | System development | Tissue development | Nuclear chromosome segregation | ||
– | Chromosome organization | Tissue development | Mitotic cell cycle process | Sister chromatid segregation | ||
CC | – | Chromosome | Plasma membrane raft | Spindle | Chromosome, centromeric region | |
– | Chromosomal part | Postsynapse | Condensed chromosome outer kinetochore | Condensed chromosome, centromeric region | ||
– | Chromosomal region | Caveola | Cytoskeleton | Spindle | ||
– | Chromosome, centromeric region | Z disc | Mitotic spindle | Kinetochore | ||
– | Nuclear lumen | Postsynaptic density | Condensed chromosome kinetochore | Condensed chromosome kinetochore | ||
MF | – | Catalytic activity, acting on DNA | 2-Aminoadipate transaminase activity | Microtubule binding | ATP binding | |
– | Protein binding | Protein-lysine 6-oxidase activity | Cell adhesion molecule binding | Adenyl ribonucleotide binding | ||
– | DNA-dependent ATPase activity | Binding | Tubulin binding | Adenyl nucleotide binding | ||
– | Chromatin binding | Kynurenine aminotransferase activity | Cytoskeletal protein binding | Microtubule binding | ||
– | ATP binding | Kynurenine-oxoglutarate transaminase activity | Kinase activity | Cell adhesion molecule binding |