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Table 5 Top 5 enriched GO terms for significantly up- and downregulated DEGs for pHPL-ASCs between P0 and subsequent passages. Related to Fig. 3b

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression Domain P0–P1 P0–P2 P0–P3 P0–P4 P0–P5
Upregulated BP Immune system process Immune system process Immune system process Immune system process Immune system process
Immune response Immune response Immune response Immune response Immune response
Inflammatory response Inflammatory response Response to external stimulus Response to external stimulus Response to external stimulus
Defense response Defense response Defense response Defense response Defense response
Cell surface receptor signaling pathway Cellular response to chemical stimulus Cellular response to chemical stimulus Inflammatory response Cellular response to chemical stimulus
CC Plasma membrane part Extracellular region Extracellular region Extracellular region Extracellular region
Intrinsic component of plasma membrane Extracellular region part Plasma membrane Intrinsic component of plasma membrane Extracellular region part
Integral component of plasma membrane Plasma membrane part Cell periphery Integral component of plasma membrane Plasma membrane part
Plasma membrane Intrinsic component of plasma membrane Intrinsic component of plasma membrane Plasma membrane part Extracellular space
Cell surface Extracellular space Plasma membrane part Extracellular region part Plasma membrane
MF Receptor activity Receptor activity Receptor activity Receptor activity Receptor binding
Molecular transducer activity Receptor binding Glycosaminoglycan binding Molecular transducer activity Receptor activity
Signal transducer activity Molecular transducer activity Molecular transducer activity Receptor binding Molecular transducer activity
Signaling receptor activity Glycosaminoglycan binding Receptor binding Glycosaminoglycan binding Glycosaminoglycan binding
Chemokine activity Cytokine binding Sulfur compound binding Peptide binding Signal transducer activity
Downregulated BP Cell cycle process Anatomical structure morphogenesis Cell cycle process Cell cycle process
Cell cycle Developmental process Cell division Cell division
Mitotic cell cycle Anatomical structure development Anatomical structure morphogenesis Chromosome segregation
Mitotic cell cycle process System development Tissue development Nuclear chromosome segregation
Chromosome organization Tissue development Mitotic cell cycle process Sister chromatid segregation
CC Chromosome Plasma membrane raft Spindle Chromosome, centromeric region
Chromosomal part Postsynapse Condensed chromosome outer kinetochore Condensed chromosome, centromeric region
Chromosomal region Caveola Cytoskeleton Spindle
Chromosome, centromeric region Z disc Mitotic spindle Kinetochore
Nuclear lumen Postsynaptic density Condensed chromosome kinetochore Condensed chromosome kinetochore
MF Catalytic activity, acting on DNA 2-Aminoadipate transaminase activity Microtubule binding ATP binding
Protein binding Protein-lysine 6-oxidase activity Cell adhesion molecule binding Adenyl ribonucleotide binding
DNA-dependent ATPase activity Binding Tubulin binding Adenyl nucleotide binding
Chromatin binding Kynurenine aminotransferase activity Cytoskeletal protein binding Microtubule binding
ATP binding Kynurenine-oxoglutarate transaminase activity Kinase activity Cell adhesion molecule binding