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Table 5 Top 5 enriched GO terms for significantly up- and downregulated DEGs for pHPL-ASCs between P0 and subsequent passages. Related to Fig. 3b

From: The effect of medium supplementation and serial passaging on the transcriptome of human adipose-derived stromal cells expanded in vitro

Gene expression

Domain

P0–P1

P0–P2

P0–P3

P0–P4

P0–P5

Upregulated

BP

Immune system process

Immune system process

Immune system process

Immune system process

Immune system process

Immune response

Immune response

Immune response

Immune response

Immune response

Inflammatory response

Inflammatory response

Response to external stimulus

Response to external stimulus

Response to external stimulus

Defense response

Defense response

Defense response

Defense response

Defense response

Cell surface receptor signaling pathway

Cellular response to chemical stimulus

Cellular response to chemical stimulus

Inflammatory response

Cellular response to chemical stimulus

CC

Plasma membrane part

Extracellular region

Extracellular region

Extracellular region

Extracellular region

Intrinsic component of plasma membrane

Extracellular region part

Plasma membrane

Intrinsic component of plasma membrane

Extracellular region part

Integral component of plasma membrane

Plasma membrane part

Cell periphery

Integral component of plasma membrane

Plasma membrane part

Plasma membrane

Intrinsic component of plasma membrane

Intrinsic component of plasma membrane

Plasma membrane part

Extracellular space

Cell surface

Extracellular space

Plasma membrane part

Extracellular region part

Plasma membrane

MF

Receptor activity

Receptor activity

Receptor activity

Receptor activity

Receptor binding

Molecular transducer activity

Receptor binding

Glycosaminoglycan binding

Molecular transducer activity

Receptor activity

Signal transducer activity

Molecular transducer activity

Molecular transducer activity

Receptor binding

Molecular transducer activity

Signaling receptor activity

Glycosaminoglycan binding

Receptor binding

Glycosaminoglycan binding

Glycosaminoglycan binding

Chemokine activity

Cytokine binding

Sulfur compound binding

Peptide binding

Signal transducer activity

Downregulated

BP

–

Cell cycle process

Anatomical structure morphogenesis

Cell cycle process

Cell cycle process

–

Cell cycle

Developmental process

Cell division

Cell division

–

Mitotic cell cycle

Anatomical structure development

Anatomical structure morphogenesis

Chromosome segregation

–

Mitotic cell cycle process

System development

Tissue development

Nuclear chromosome segregation

–

Chromosome organization

Tissue development

Mitotic cell cycle process

Sister chromatid segregation

CC

–

Chromosome

Plasma membrane raft

Spindle

Chromosome, centromeric region

–

Chromosomal part

Postsynapse

Condensed chromosome outer kinetochore

Condensed chromosome, centromeric region

–

Chromosomal region

Caveola

Cytoskeleton

Spindle

–

Chromosome, centromeric region

Z disc

Mitotic spindle

Kinetochore

–

Nuclear lumen

Postsynaptic density

Condensed chromosome kinetochore

Condensed chromosome kinetochore

MF

–

Catalytic activity, acting on DNA

2-Aminoadipate transaminase activity

Microtubule binding

ATP binding

–

Protein binding

Protein-lysine 6-oxidase activity

Cell adhesion molecule binding

Adenyl ribonucleotide binding

–

DNA-dependent ATPase activity

Binding

Tubulin binding

Adenyl nucleotide binding

–

Chromatin binding

Kynurenine aminotransferase activity

Cytoskeletal protein binding

Microtubule binding

–

ATP binding

Kynurenine-oxoglutarate transaminase activity

Kinase activity

Cell adhesion molecule binding